Thursday, February 18, 2010

Universes within Universes

Agarose gel (1% Trevigel)



Guo X et al. Genome Res. 2003;13:1810-1817, 2003 by Cold Spring Harbor Laboratory Press
Guo, Xianwu; Flores, Margarita; Mavingui, Patrick; et al. "Natural Genomic Design in Sinorhizobium meliloti: Novel Genomic Architectures" Genome Research, Cold Spring Harbor Laboratory Press. 2003;13:1810-1817. Online.

Pulse-field gel electrophoresis. Replicon structure of S. meliloti 1021 and derivative strains.
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Breathtaking images of a genetics lab technique called gel electrophoresis.  The first image reminds me of headlights on the road at night, ice, illuminated high-rise windows, and dancing stars.  And the second image brings to mind india ink brushstrokes, and x-ray skeletons.  Universes within universes.

Scientists use gel electrophoresis to separate DNA molecules by size.  Each band you see represents the accumulation of molecules of the same length.  A common method of viewing these separate bands is to stain the gel with ethidium bromide, so that the bands of DNA will fluoresce when illuminated with UV light.

Imagine these printed on fabric, so that we could 'wear' our DNA.
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